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Ciclohale inhaler (Alvesco; Sepracor), an inhaled, was approved by the FDA in 2006 for maintenance treatment of asthma in patients aged 12 years and older. Ciclohale Inhaler is a prodrug that is hydrolyzed to its active metabolite, C21-desisobutyryl-ciclesonide, following oral inhalation.
Its mechanism of action includes inflammatory-cell migration and activation, reduced airway hyperresponsiveness, and blockade of late-phase allergic reactions.