Oncotrex Tablets

With the assistance of advanced machines, equipment and quality packing material, we pack the products in safe and rapid manner. In addition, we make sure that the entire lot is checked before dispatch. With the due assistance of our deft professionals, we are making available top-of-the-line quality products from Nagpur(India). Oncotrex Tablets are used for the treatment of various types of the cancer like skin, head, neck, lung, breast etc.

Details : Oncotrex(Methotrexate), abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases. It acts by inhibiting the metabolism of folic acid. Methotrexate began to replace the more powerful and toxic antifolate aminopterin starting in the 1950s, and the two should not be confused with each other.

PharmacodynamicsPharmacokinetics : Methotrexate is a folic acid antagonist that inhibits DNA synthesis. It irreversibly binds to dihydrofolate reductase, inhibiting the formation of reduced folates, and thymidylate synthetase, resulting in inhibition of purine and thymidylic acid synthesis.

Absorption : Rapidly absorbed from the GI tract at low doses, higher doses are less well absorbed. Rapidly and completely absorbed after IM doses. Peak plasma concentrations after 1-2 hours (oral), 30-60 minutes (IM).

Distribution : Tissues and extracellular fluids; crosses the blood-brain barrier and placenta; enters breast milk. Small amounts in saliva and breastmilk. 50% bound to plasma proteins. Bound as polyglutamate conjugates, bound drug may remain in the body for several months, particularly in the liver .

Metabolism :

• Partly by intestinal flora. Does not undergo significant metabolism at low dose therapy; 7-hydroxy metabolite is detected at high-doses.
• Excretion Primarily via urine; small amounts in bile, faeces. Some evidence of enterohepatic recirculation. Interindividual variation exists, patients with delayed clearance are at an increased risk of toxicity.